2008 Pittsburgh Panthers Schedule
| Date | Time (ET) | Opponent | Result | Record |
| 08/30/2008 | 12:00 PM | Bowling Green | L, 27-17 | 0-1-0 |
| 09/06/2008 | 06:00 PM | Buffalo | W, 27-16 | 1-1-0 |
| 09/20/2008 | 12:00 PM | Iowa | W, 21-20 | 2-1-0 |
| 09/27/2008 | 12:00 PM | at Syracuse | W, 34-24 | 3-1-0 |
| 10/02/2008 | 07:30 PM | at So Florida | W, 26-21 | 4-1-0 |
| 10/18/2008 | 03:30 PM | at Navy | W, 42-21 | 5-1-0 |
| 10/25/2008 | 03:30 PM | Rutgers | L, 54-34 | 5-2-0 |
| 11/01/2008 | 02:30 PM | at Notre Dame | W, 36-33 | 6-2-0 |
| 11/08/2008 | 12:00 PM | Louisville | W, 41-7 | 7-2-0 |
| 11/22/2008 | 07:15 PM | at Cincinnati | L, 28-21 | 7-3-0 |
| 11/28/2008 | 12:00 PM | West Virginia | W, 19-15 | 8-3-0 |
| 12/06/2008 | 12:00 PM | at Connecticut | W, 34-10 | 9-3-0 |
| 12/31/2008 | 02:15 PM | Oregon State |
